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Peptide record

TPDB08009

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08009
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VNWKKILAKIIKVVK
Physicochemical Analysis
C87H154N22O17
RDCEQGHMFPSTY
K
1780.32
11.12
5
0
9
+5
2.07
0.520
168.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
308.93
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
1
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
15
C87H154N22O17
1780.32
11.12
+5
2.07
0.520
Evidence Records 7 records
Evidence 1 Activity

Activity

LC50
Hemolysis
55.1 µM
[Ref.19591185]LC50=55.1 µM against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Chembiochem. 2009 Aug 17 10(12):2089-2111.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
55.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 55.1 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). | Chembiochem | 2009
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
10±2 µM
Cytotoxic
IC50 | 10±2 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 5 Activity

Activity

IC50
Toxicity
18±5 µM
Cytotoxic
IC50 | 18±5 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 6 Activity

Activity

LC50
Toxicity
55.1 µM
Hemolytic
Hemolytic_activity: [Ref.19591185]LC50=55.1 µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2009 Aug 17 10(12):2089-2111.
Evidence 7 Hemolysis

Activity

55.1 µM
LC50
[Ref.19591185]LC50=55.1 µM against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

PD_Hemolysis
Chembiochem. 2009 Aug 17 10(12):2089-2111.
DRAMP4
PD_Hemolysis