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Peptide record

TPDB08007

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08007
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLLSGILGAGKKIVF
Physicochemical Analysis
C70H121N17O17
RNDCEQHMPTWY
G
1472.83
10.60
2
0
8
+2
-1.38
1.267
156.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
2
I
3
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 3 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C70H121N17O17
1472.83
10.60
+2
-1.38
1.267
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.9 µM

Target

Staphylococcus aureus NCTC10788

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µM

Target

Escherichia coli NCTC10418

Source & Reference

dbAMP

Other

Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the
Evidence 3 Activity

Activity

MIC
Antibacterial
47 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the peptide is more active against Gram+
Evidence 4 Activity

Activity

MIC
Antibacterial
2.9 µM

Target

Candida albicans NCYC1467

Source & Reference

dbAMP

Other

788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the peptide is more active against Gram+ bacteria and fungi.
Evidence 5 Activity

Activity

MIC
Antifungal
2.9 µM

Target

Staphylococcus aureus NCTC10788

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC
Evidence 6 Activity

Activity

MIC
Antifungal
12 µM

Target

Escherichia coli NCTC10418

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the
Evidence 7 Activity

Activity

MIC
Antifungal
47 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus NCTC10788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the peptide is more active against Gram+
Evidence 8 Activity

Activity

MIC
Antifungal
2.9 µM

Target

Candida albicans NCYC1467

Source & Reference

dbAMP CAFPdb Antifungipept

Other

788 (MIC 2.9 uM), E. coli NCTC10418 (MIC 12 uM), P. aeruginosa ATCC27853 (MIC 47 uM), and C. albicans NCYC1467 (MIC 2.9 uM). Clearly, the peptide is more active against Gram+ bacteria and fungi.
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Modification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria. | Front Microbiol | 2018
Evidence 10 Activity

Activity

12% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
12% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Modification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria. | Front Microbiol | 2018
Evidence 11 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Modification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria. | Front Microbiol | 2018