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Peptide record

TPDB07995

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07995
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RSMRLSFRARGYGFR
Physicochemical Analysis
C81H130N30O19S1
NDCEQHIKPTWV
R
1860.17
12.58
5
0
6
+5
0.17
-0.873
32.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
80.10
3
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
0
K
1
M
2
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 1 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C81H130N30O19S1
1860.17
12.58
+5
0.17
-0.873
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

M. luteus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous f
Evidence 2 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

B. megaterium

Source & Reference

dbAMP

Other

Active against Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli D22

Source & Reference

dbAMP

Other

Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

N. grassa

Source & Reference

dbAMP

Other

megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysp
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. fumigatus

Source & Reference

dbAMP

Other

Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentag
Evidence 6 Activity

Activity

MIC
Antibacterial
0.2 µM

Target

N. haematococca

Source & Reference

dbAMP

Other

coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cel
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

F. culmorum

Source & Reference

dbAMP

Other

ous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2
Evidence 8 Activity

Activity

MIC
Antibacterial
6 µM

Target

F. oxysporum

Source & Reference

dbAMP

Other

1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µM

Target

T. mentagrophytes

Source & Reference

dbAMP

Other

IC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM)
Evidence 10 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see
Evidence 11 Activity

Activity

MIC
Antibacterial
1.8 µM

Target

C. tropicalis

Source & Reference

dbAMP

Other

oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active agains
Evidence 12 Activity

Activity

MIC
Antibacterial
8 µM

Target

C. glabrata

Source & Reference

dbAMP

Other

tagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active against C. albicans (MIC 2.9 u
Evidence 13 Activity

Activity

MIC
Antibacterial
1.4 µM

Target

C. neoformans

Source & Reference

dbAMP

Other

t cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active against C. albicans (MIC 2.9 uM for the D-form and 4.2 uM for
Evidence 14 Activity

Activity

MIC
Antifungal
0.8 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous f
Evidence 15 Activity

Activity

MIC
Antifungal
0.8 µM

Target

B. megaterium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM),
Evidence 16 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli D22

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Gram-positive M. luteus (MIC 0.8 uM), B. megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC
Evidence 17 Activity

Activity

MIC
Antifungal
1.2 µM

Target

N. grassa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

megaterium (MIC 0.8 uM), Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysp
Evidence 18 Activity

Activity

MIC
Antifungal
10 µM

Target

A. fumigatus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Gram-negative bacteria E. coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentag
Evidence 19 Activity

Activity

MIC
Antifungal
0.2 µM

Target

N. haematococca

Source & Reference

dbAMP CAFPdb Antifungipept

Other

coli D22 (MIC 8 uM), Filamentous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cel
Evidence 20 Activity

Activity

MIC
Antifungal
2 µM

Target

F. culmorum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ous fungi N. grassa (MIC 1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2
Evidence 21 Activity

Activity

MIC
Antifungal
6 µM

Target

F. oxysporum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.2 uM), A. fumigatus (MIC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1
Evidence 22 Activity

Activity

MIC
Antifungal
4 µM

Target

T. mentagrophytes

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 10 uM), N. haematococca (MIC 0.2 uM), F. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM)
Evidence 23 Activity

Activity

MIC
Antifungal
1.2 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. culmorum (MIC 2 uM), F. oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see
Evidence 24 Activity

Activity

MIC
Antifungal
1.8 µM

Target

C. tropicalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

oxysporum (MIC 6 uM), T. mentagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active agains
Evidence 25 Activity

Activity

MIC
Antifungal
8 µM

Target

C. glabrata

Source & Reference

dbAMP CAFPdb Antifungipept

Other

tagrophytes (MIC 4 uM), yeast cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active against C. albicans (MIC 2.9 u
Evidence 26 Activity

Activity

MIC
Antifungal
1.4 µM

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

t cells C. albicans (MIC 1.2 uM), C. tropicalis (MIC 1.8 uM), C. glabrata (MIC 8 uM), and C. neoformans (MIC 1.4 uM) (see the ref). Also active against C. albicans (MIC 2.9 uM for the D-form and 4.2 uM for
Evidence 27 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A. | Cell Mol Life Sci | 2005
Evidence 28 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
D-Cateslytin, a new antimicrobial peptide with therapeutic potential | Sci Rep | 2017
Evidence 29 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human gingival fibroblasts

Target

Human gingival fibroblasts

Source & Reference

NA
DBAASP
D-Cateslytin: a new antifungal agent for the treatment of oral Candida albicans associated infections. | Sci Rep | 2018