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Peptide record

TPDB07988

Antibacterial Antifungal Antiparasitic Antiviral Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07988
Antibacterial Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ALHKTMLKKLGTMAL
Physicochemical Analysis
C74H134N20O18S2
RNDCEQIFPSWYV
L
1656.12
10.84
4
0
8
+3
1.18
0.393
117.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
4
L
3
K
2
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 4 K: 3 M: 2 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C74H134N20O18S2
1656.12
10.84
+3
1.18
0.393
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50=100 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50>100 µM 293TT(embryonic human culture cells):CC50>100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.