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Peptide record

TPDB07925

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07925
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LVKLVAGIKKFLKWK
Physicochemical Analysis
C89H151N21O16
RNDCEQHMPSTY
K
1771.31
11.12
5
0
9
+5
-0.04
0.540
149.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
310.50
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15
C89H151N21O16
1771.31
11.12
+5
-0.04
0.540
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
64-128 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP

Other

active against Gram+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 u
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

S.pneumoniae ATCC 49619

Source & Reference

dbAMP

Other

am+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 u
Evidence 4 Activity

Activity

MIC
Antibacterial
64-128 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP

Other

eus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

umoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albic
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.g
Evidence 7 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

A.niger ATCC 16404

Source & Reference

dbAMP

Other

l), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainl
Evidence 8 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainly Gram-.
Evidence 9 Activity

Activity

MIC
Antibacterial
>256 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP

Other

ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainly Gram-.
Evidence 10 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml)
Evidence 11 Activity

Activity

MIC
Antifungal
64-128 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 u
Evidence 12 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

S.pneumoniae ATCC 49619

Source & Reference

dbAMP CAFPdb Antifungipept

Other

am+ E. faecalis PCM 2673 (MIC 64 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 u
Evidence 13 Activity

Activity

MIC
Antifungal
64-128 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eus ATCC 25923 or 9144 (MIC 64-128 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.
Evidence 14 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

umoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albic
Evidence 15 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.g
Evidence 16 Activity

Activity

MIC
Antifungal
256 µg/mL

Target

A.niger ATCC 16404

Source & Reference

dbAMP CAFPdb Antifungipept

Other

l), K. pneumoniae ATCC 700603 (MIC 2 ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainl
Evidence 17 Activity

Activity

MIC
Antifungal
256 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 8 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainly Gram-.
Evidence 18 Activity

Activity

MIC
Antifungal
>256 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 256 ug/ml), and C.glabrata ATCC 15126 (MIC >256 ug/ml). mainly Gram-.
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 20 Activity

Activity

10% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017