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Peptide record

TPDB07913

Antibacterial standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07913
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWKLFKGIRAVLKVL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C89H151N23O16
NDCEQHMPSTY
K
1799.32
11.80
5
0
9
+5
0.09
0.500
149.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
3.06
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15 reviewed residue count
C89H151N23O16 sequence-only estimate (linear, free termini)
1799.32 sequence-only estimate (linear, free termini)
11.80 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
0.09 sequence-only estimate (linear, free termini)
0.500 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

active against 10 clinical anaerobic strains Peptostreptococcus spp. (MIC90 4 ug/ml MIC50 4 ug/ml), 10 clinical anaerobic strains Propionibacterium (MIC90 2 ug/ml MIC50 2 ug/ml), 10 clinical anaerobic strains C. difficile (MIC90 4 ug/ml MIC50 4 ug/ml), 10 clinical anaerobic strains B. fragilis (MIC90 4 ug/ml MIC50 2 ug/ml), 10 clinical anaerobic strains Prevotella spp. (MIC90 4 ug/ml MIC50 4 ug/ml), 10 clinical anaerobic strains F. nucleatum (MIC90 4 ug/ml MIC50 4 ug/ml).