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Peptide record

TPDB07850

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07850
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLLRPLLQLLKQKLR
Physicochemical Analysis
C87H162N28O18
ANDCEGHIMFSTWYV
L
1888.42
12.71
5
0
7
+5
2.10
-0.220
182.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
7
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 7 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C87H162N28O18
1888.42
12.71
+5
2.10
-0.220
Evidence Records 27 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomyci
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MI
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

E. faecium VRE

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

(MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP

Other

VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/m
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/m
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 u
Evidence 9 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 10 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 11 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

himurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomyci
Evidence 13 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MI
Evidence 14 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

E. faecium VRE

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 2 ug/ml), E. faecalis (MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA
Evidence 15 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 2 ug/ml), E. faecium VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml
Evidence 16 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

VRE (MIC 2 ug/ml) (anti-VRE. cf.: MIC of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml),
Evidence 17 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

of vancomycin >32 ug/ml), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/m
Evidence 18 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), M. luteus (MIC 2 ug/ml), S. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/m
Evidence 19 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. aureus or MRSA (MIC 2 ug/ml), Gram- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 u
Evidence 20 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

- E. coli (MIC 2 ug/ml), P. aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 21 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aeruginosa (MIC 2 ug/ml), S. typhimurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 22 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

himurium (MIC 2 ug/ml), fungi C. albicans (MIC 2 ug/ml), C. neoformans (MIC 2 ug/ml), and S. cerevisiae (MIC 2 ug/ml).
Evidence 23 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 24 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 25 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 26 Activity

Activity

2% Hemolysis
Toxicity
65 µM
Hemolytic Cytotoxic
2% Hemolysis | 65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of a Novel Hybrid Antimicrobial Peptide for Targeted Killing of Pseudomonas Aeruginosa. | Eur J Med Chem | 2020
Evidence 27 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells | Cytotoxicity: [Ref.23946320] The cell viability of hPBMCs is at peptide concentrations of 4, 8, 16, 32, 64 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Antimicrob Chemother. 2014 Jan 69(1):121-32. doi: 10.1093/jac/dkt322.