Back to search

Peptide record

TPDB07828

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07828
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RVVRPVVQVVKQKVR
Physicochemical Analysis
C80H148N28O18
ANDCEGHILMFSTWY
V
1790.23
12.71
5
0
7
+5
6.51
-0.033
135.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
7
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 7
Chemical Descriptors
15
C80H148N28O18
1790.23
12.71
+5
6.51
-0.033
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. | J Antimicrob Chemother | 2014
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells | Cytotoxicity: [Ref.23946320] The cell viability of hPBMCs is at peptide concentrations of 4, 8, 16, 32, 64 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Antimicrob Chemother. 2014 Jan 69(1):121-32. doi: 10.1093/jac/dkt322.