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Peptide record

TPDB07825

LPcin (1-15)[T2K,T6W] LPcin-YK3 Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07825
LPcin (1-15)[T2K,T6W] LPcin-YK3
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia DBAASP
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and DBAASP, with an available 3D structural model.
Sequence
NKVKEWIKYLKSLFS
Physicochemical Analysis
C91H143N21O22
ARDCQGHMPT
K
1883.26
10.31
4
1
7
+3
1.38
-0.487
97.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
6990
371.16
4
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
1
I
2
L
4
K
0
M
1
F
0
P
2
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 4 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
15
C91H143N21O22
1883.26
10.31
+3
1.38
-0.487
Evidence Records 8 records
Evidence 1 Activity

Activity

IC50
Toxicity
99.1 µM
Cytotoxic
IC50 | 99.1 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2017
Evidence 2 Activity

Activity

IC50
Toxicity
94.0 µM
Cytotoxic
IC50 | 94.0 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2017
Evidence 4 Activity

Activity

IC50
Toxicity
76.0 µM
Cytotoxic
IC50 | 76.0 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2017
Evidence 5 Activity

Activity

IC50
Toxicity
56.2 µM
Cytotoxic
IC50 | 56.2 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2017
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2018
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin. | J Microbiol Biotechnol | 2018
Evidence 8 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP