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Peptide record

TPDB07801

Antibacterial Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07801
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 15-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
KWKKFKKIGAVLKVL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C89H152N22O16
RNDCEQHMPSTY
K
1786.32
11.21
6
0
8
+6
0.16
0.027
123.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
3.08
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15 reviewed residue count
C89H152N22O16 sequence-only estimate (linear, free termini)
1786.32 sequence-only estimate (linear, free termini)
11.21 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
0.16 sequence-only estimate (linear, free termini)
0.027 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

21% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
21% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity. | Antimicrob Agents Chemother | 2008
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis