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Peptide record

TPDB07797

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB07797
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
FLGGLIKWPWWPWRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C103H140N26O16
ANDCEQHMSTYV
W
1998.41
12.41
3
0
8
+3
0.43
-0.373
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
22000
11.01
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
1
K
0
M
1
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 1 M: 0 F: 1 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
15 reviewed residue count
C103H140N26O16 sequence-only estimate (linear, free termini)
1998.41 sequence-only estimate (linear, free termini)
12.41 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.43 sequence-only estimate (linear, free termini)
-0.373 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

100% hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
100% hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
15.62 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 15.62 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 4 Activity

Activity

50% Cell death
Toxicity
125 µg/mL
Cytotoxic
50% Cell death | 125 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015