Back to search

Peptide record

TPDB07749

Antibacterial Antifungal Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07749
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
VKRWKKFWRKWKKWW
Physicochemical Analysis
C117H166N32O16
ANDCEQGHILMPSTY
K
2276.81
12.46
8
0
7
+8
-2.75
-1.993
19.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
27500
1207.83
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
1
F
0
P
0
S
0
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 1
Chemical Descriptors
15
C117H166N32O16
2276.81
12.46
+8
-2.75
-1.993
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
51.7±5.3 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 51.7±5.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 3 Activity

Activity

28% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
28% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis