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Peptide record

TPDB07739

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07739
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VWPLGLVICKALKIC
Physicochemical Analysis
C79H134N18O16S2
RNDEQHMFSTY
L
1656.16
9.11
2
0
9
+2
-2.22
1.660
175.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5625
339.64
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
3
L
2
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15
C79H134N18O16S2
1656.16
9.11
+2
-2.22
1.660
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.9 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysent
Evidence 2 Activity

Activity

MIC
Antibacterial
1.9 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E.
Evidence 3 Activity

Activity

MIC
Antibacterial
3.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneu
Evidence 4 Activity

Activity

MIC
Antibacterial
3.8 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabi
Evidence 5 Activity

Activity

MIC
Antibacterial
18.1 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP

Other

C 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 6 Activity

Activity

MIC
Antibacterial
9.1 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 7 Activity

Activity

MIC
Antibacterial
9.1 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/m
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
0.9 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysent
Evidence 11 Activity

Activity

MIC
Antifungal
1.9 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E.
Evidence 12 Activity

Activity

MIC
Antifungal
3.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneu
Evidence 13 Activity

Activity

MIC
Antifungal
3.8 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabi
Evidence 14 Activity

Activity

MIC
Antifungal
18.1 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 15 Activity

Activity

MIC
Antifungal
9.1 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 16 Activity

Activity

MIC
Antifungal
9.1 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/m
Evidence 17 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiparasitic
0.9 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysent
Evidence 20 Activity

Activity

MIC
Antiparasitic
1.9 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E.
Evidence 21 Activity

Activity

MIC
Antiparasitic
3.8 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneu
Evidence 22 Activity

Activity

MIC
Antiparasitic
3.8 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabi
Evidence 23 Activity

Activity

MIC
Antiparasitic
18.1 µM

Target

S. dysenteriae

Source & Reference

DRAMP

Other

C 0.9 uM), S. aureus (MIC 1.9 uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 24 Activity

Activity

MIC
Antiparasitic
9.1 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

uM), B. subtilis (MIC 3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 25 Activity

Activity

MIC
Antiparasitic
9.1 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

3.8 uM), S. epidermidis (MIC 3.8 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/m
Evidence 26 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.aeruginosa

Source & Reference

DRAMP

Other

18.1 uM), E. coli (MIC 9.1 uM), K. pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 27 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

pneumoniae (MIC 9.1 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 28 Activity

Activity

% Hemolysis
Hemolysis
47.58 %
[Ref:17698251] It has 47.58% hemolytic activity at 100 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides 2007 28: 1532-1539.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 29 Activity

Activity

48% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
48% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. | Peptides | 2007
Evidence 30 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17698251] It has 47.58% hemolytic activity at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 2007 28: 1532-1539.
Evidence 31 Hemolysis

Activity

47.58 %
% Hemolysis
[Ref:17698251] It has 47.58% hemolytic activity at 100 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Peptides 2007 28: 1532-1539.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.