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Peptide record

TPDB07713

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07713
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KLLKLVKKVVGALG
Physicochemical Analysis
C70H132N18O15
RNDCEQHIMFPSTWY
LK
1465.93
11.00
4
0
8
+4
1.78
0.943
180.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
14
C70H132N18O15
1465.93
11.00
+4
1.78
0.943
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
5% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
533 µM
Cytotoxic
50% Cell death | 533 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020