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Peptide record

TPDB07712

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07712
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GVVKKVVKKVVKKV
Physicochemical Analysis
C73H140N20O15
ARNDCEQHILMFPSTWY
V
1538.04
11.21
6
0
7
+6
6.44
0.400
145.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
7
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 7
Chemical Descriptors
14
C73H140N20O15
1538.04
11.21
+6
6.44
0.400
Evidence Records 3 records
Evidence 1 Activity

Activity

8% Killing
Toxicity
40 µM
Cytotoxic
8% Killing | 40 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
0% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 250 µM | Cytotoxicity: Human keratinocytes HaCat: <30% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP