TPDB

3D PDB MODEL

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TPDB ID TPDB07697

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

ISRACLIMKVRRKK

FASTA

>TPDB07697|Antibacterial;Antifungal|length=14
ISRACLIMKVRRKK

Formula C73H140N26O16S2

Absent Amino Acids NDEQGHFPTWY

Common Amino Acids RK

Mass 1702.20

PI 12.14

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 3.78

Hydrophobicity -0.200

Aliphatic Index 111.43

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

3

R

0

N

0

D

1

C

0

E

0

Q

0

G

0

H

2

I

1

L

3

K

1

M

0

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

14

Formula

C73H140N26O16S2

Mass

1702.20

PI

12.14

Net Charge

+6

Boman Index

3.78

Hydrophobicity

-0.200

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.4 µM

Target

Target Organism B. subtilis 168 HT

Source & Reference

Database Source NA

Other

Evidence Text

Active againstB. subtilis 168 HT (MIC 9.4 uM). E. coli MG1655 (MIC 37.6 uM), and C. trachomatis D/UW-3/Cx (MIC90 12.5 uM). Note that wh

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.6 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

Active againstB. subtilis 168 HT (MIC 9.4 uM). E. coli MG1655 (MIC 37.6 uM), and C. trachomatis D/UW-3/Cx (MIC90 12.5 uM). Note that whether this is a or part of the

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.4 µM

Target

Target Organism B. subtilis 168 HT

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active againstB. subtilis 168 HT (MIC 9.4 uM). E. coli MG1655 (MIC 37.6 uM), and C. trachomatis D/UW-3/Cx (MIC90 12.5 uM). Note that wh

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.6 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active againstB. subtilis 168 HT (MIC 9.4 uM). E. coli MG1655 (MIC 37.6 uM), and C. trachomatis D/UW-3/Cx (MIC90 12.5 uM). Note that whether this is a or part of the