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Peptide record

TPDB07688

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07688
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LKKLCARLKKLCAR
Physicochemical Analysis
C72H138N24O15S2
NDEQGHIMFPSTWYV
LK
1644.16
10.97
6
0
6
+6
2.52
-0.057
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
7.60
2
Residue Composition
number
2
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C72H138N24O15S2
1644.16
10.97
+6
2.52
-0.057
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse primary corneal epithelial cells (MPCE)

Target

Mouse primary corneal epithelial cells (MPCE)

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020