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Peptide record

TPDB07687

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07687
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KLLKLLKKVVGALG
Physicochemical Analysis
C71H134N18O15
RNDCEQHIMFPSTWY
L
1479.96
11.00
4
0
8
+4
1.15
0.914
187.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
5
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
14
C71H134N18O15
1479.96
11.00
+4
1.15
0.914
Evidence Records 3 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
<=5% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
67 µM
Cytotoxic
50% Cell death | 67 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>21 µM
Cytotoxic
50% Cell death | >21 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020