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Peptide record

TPDB07659

Pantinin-1 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07659
Pantinin-1
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILGKLWEGFKSIV
Physicochemical Analysis
C75H119N17O18
ARNDCQHMPTY
G
1546.87
9.88
2
1
7
+1
-0.49
0.671
132.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
355.56
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C75H119N17O18
1546.87
9.88
+1
-0.49
0.671
Free
L
Linear
Free
Antimicrobial
Synthetic
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-32 µM

Target

MRSA 16472

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ve S. aureus AB 94004, B. magaterium AB 90008, M. luteus AB2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 8-32 uM), Gram-negative E. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76
Evidence 2 Activity

Activity

MIC
Antibacterial
62-76 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP

Other

ti-VRE), MRSA 16472 (MIC 8-32 uM), Gram-negative E. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP

Other

. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 4 Activity

Activity

IC50
IC50 = 28.5 ± 1.0 µM
Anticancer
28.5

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

IC50
IC50 = 47.5 ± 2.0 µM
Anticancer
47.5

Target

Prostate Cancer
DU-145
Prostate

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
Evidence 6 Activity

Activity

MIC
Antifungal
8-32 µM

Target

MRSA 16472

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ve S. aureus AB 94004, B. magaterium AB 90008, M. luteus AB2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 8-32 uM), Gram-negative E. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76
Evidence 7 Activity

Activity

MIC
Antifungal
62-76 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ti-VRE), MRSA 16472 (MIC 8-32 uM), Gram-negative E. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
16 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. coli DH5alpha, E. cloacae AB 2010162, S. enterica AB 2010185 (MIC 62-76 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 9 Activity

Activity

% Hemolysis
Hemolysis
0 0 20 %
[Ref.23624072]0% hemolytic activity at 16 µM, 0% hemolytic activity at 32 µM, 20% hemolytic activity at 64 µM against human red bood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides 45:28-34(2013)##Peptides 51:35-45(2014

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

21% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
21% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013
Evidence 11 Activity

Activity

IC50
Toxicity
97.5±1.0 µM
Cytotoxic
IC50 | 97.5±1.0 | µM | target cell: Human gingival fibroblasts

Target

Human gingival fibroblasts

Source & Reference

NA
DBAASP
Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom | Biochim Biophys Acta | 2018
Evidence 12 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23624072]0% hemolytic activity at 16 µM, 0% hemolytic activity at 32 µM, 20% hemolytic activity at 64 µM against human red bood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 45:28-34(2013)##Peptides 51:35-45(2014
Evidence 13 Hemolysis

Activity

0 0 20 %
% Hemolysis
[Ref.23624072]0% hemolytic activity at 16 µM, 0% hemolytic activity at 32 µM, 20% hemolytic activity at 64 µM against human red bood cells
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides 45:28-34(2013)##Peptides 51:35-45(2014
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.