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Peptide record

TPDB07658

Antibacterial Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07658
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFWGKLWEGVKNAI
Physicochemical Analysis
C78H113N19O18
RDCQHMPSTY
G
1604.87
9.88
2
1
7
+1
-1.35
-0.050
83.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
685.41
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
0
Q
3
G
0
H
1
I
1
L
2
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
14
C78H113N19O18
1604.87
9.88
+1
-1.35
-0.050
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10-15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus, P. aeruginosa, and E. coli (MIC 10-15 uM). Updated Jan2013.
Evidence 2 Activity

Activity

MIC
Antifungal
10-15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus, P. aeruginosa, and E. coli (MIC 10-15 uM). Updated Jan2013.
Evidence 3 Activity

Activity

% Hemolysis
Hemolysis
20 45 80 90 %
[Ref.23182832]20% hemolytic activity at 12.5 µM, 45% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Toxicon. 2013 Mar 1 63:44-54.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

26% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
26% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 5 Activity

Activity

17% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
17% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 6 Activity

Activity

81% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
81% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
22.8±1.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 22.8±1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. | Biochim Biophys Acta | 2014
Evidence 8 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23182832]20% hemolytic activity at 12.5 µM, 45% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2013 Mar 1 63:44-54.
Evidence 9 Hemolysis

Activity

20 45 80 90 %
% Hemolysis
[Ref.23182832]20% hemolytic activity at 12.5 µM, 45% hemolytic activity at 25 µM, 80% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete PD_Hemolysis
Toxicon. 2013 Mar 1 63:44-54.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.