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Peptide record

TPDB07651

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07651

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

NILNTIINLAKKIL

FASTA

>TPDB07651|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=14
NILNTIINLAKKIL

Formula C73H133N19O19

Absent Amino Acids RDCEQGHMFPSWYV

Common Amino Acids I

Mass 1580.97

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +2

Boman Index 0.29

Hydrophobicity 0.871

Aliphatic Index 202.14

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 3 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C73H133N19O19

Mass

1580.97

10.60

Net Charge

Boman Index

0.29

Hydrophobicity

0.871

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.8 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19 µM

Target

Target Organism S. carnosus KHS

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faec

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19 um

Target

Target Organism B. licheniformis X39

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.4 µM

Target

Target Organism R. rhodochrous X15

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

eus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans A

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5 µM

Target

Target Organism P. faecalis X29

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.5 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.8 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19 µM

Target

Target Organism S. carnosus KHS

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faec

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19 um

Target

Target Organism B. licheniformis X39

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.4 µM

Target

Target Organism R. rhodochrous X15

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5 µM

Target

Target Organism P. faecalis X29

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.5 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.8 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19 µM

Target

Target Organism S. carnosus KHS

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faec

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19 um

Target

Target Organism B. licheniformis X39

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.4 µM

Target

Target Organism R. rhodochrous X15

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 37.5 µM

Target

Target Organism P. faecalis X29

Source & Reference

Database Source DRAMP

Other

Evidence Text

19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.5 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.8 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 19 µM

Target

Target Organism S. carnosus KHS

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faec

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 19 um

Target

Target Organism B. licheniformis X39

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592 (MIC 4.8 uM), S. carnosus KHS (MIC 19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.4 µM

Target

Target Organism R. rhodochrous X15

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 37.5 µM

Target

Target Organism P. faecalis X29

Source & Reference

Database Source DRAMP

Other

Evidence Text

19 uM), B. licheniformis X39 (MIC 19 um), R. rhodochrous X15 (MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 9.5 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 2.4 uM) Gram-negative P. faecalis X29 (MIC 37.5 uM), and fungi S. mould 090223 and C. albicans ATCC2002 (MIC 9.5 uM). Updated 7/2021

Evidence 25 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 300 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis. | Peptides | 2012