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Peptide record

TPDB07646

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

14 amino acids

3D PDB MODEL

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TPDB ID TPDB07646

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

NFLGTLVNLAKKIL

FASTA

>TPDB07646|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=14
NFLGTLVNLAKKIL

Formula C73H126N18O18

Absent Amino Acids RDCEQHMPSWY

Common Amino Acids L

Mass 1543.91

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +2

Boman Index -0.81

Hydrophobicity 0.900

Aliphatic Index 167.14

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C73H126N18O18

Mass

1543.91

10.60

Net Charge

Boman Index

-0.81

Hydrophobicity

0.900

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-20 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40-64 µM

Target

Target Organism Escherichia coli ATCC 25726

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 80 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-20 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 40-64 µM

Target

Target Organism Escherichia coli ATCC 25726

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 80 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16-20 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 40-64 µM

Target

Target Organism Escherichia coli ATCC 25726

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 80 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 16-20 uM) and E. coli ATCC 25726 (MIC 40-64 uM), C. albicans (MIC 80 uM).

Evidence 10 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50-65 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 50-65 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 11 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.