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Peptide record

TPDB07644

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07644

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

INWLKLGKKILGAL

FASTA

>TPDB07644|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=14
INWLKLGKKILGAL

Formula C76H131N19O16

Absent Amino Acids RDCEQHMFPSTYV

Common Amino Acids L

Mass 1566.99

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index -1.47

Hydrophobicity 0.650

Aliphatic Index 174.29

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 350.99

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C76H131N19O16

Mass

1566.99

10.84

Net Charge

Boman Index

-1.47

Hydrophobicity

0.650

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50-150 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (MIC 50-150 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50-150 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

s (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (MIC 50-150 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50-150 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (MIC 50-150 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 70 uM) and B. subtilis (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50-150 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 15.5 uM). Also active against S. aureus (more potent than against B. subtilis) and P. aeruginosa (MIC 50-150 uM).

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Hemolysis

Activity Measurement 45 µM

Hemolysis Raw

[Ref.18375018]IC50=45 µM against rat red blood cells

Target

RBC Target rat red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2008 Jun 29(6):992-1003.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 45 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 45 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs | Peptides | 2008

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 45 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.18375018]IC50=45 µM against rat red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2008 Jun 29(6):992-1003.

Evidence 16 Hemolysis

Activity

Activity Measurement 45 µM

Activity Endpoint IC50

Hemolysis Raw

[Ref.18375018]IC50=45 µM against rat red blood cells

Detail Source Activity Hemolysis

Target

RBC Target rat red blood cells

Source & Reference

source APD_complete PD_Hemolysis

Reference

Peptides. 2008 Jun 29(6):992-1003.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.