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Peptide record

TPDB07640

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07640
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
HFLGTLVNLAKKIL
Physicochemical Analysis
C75H127N19O17
RDCEQMPSWY
L
1566.95
10.60
3
0
8
+2
-0.27
0.921
167.14
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
4
L
2
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C75H127N19O17
1566.95
10.60
+2
-0.27
0.921
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 3 Activity

Activity

MIC
Antibacterial
40 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 4 Activity

Activity

MIC
Antibacterial
30 µM

Target

P. acnes

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 5 Activity

Activity

MIC
Antifungal
20 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020
Evidence 6 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 7 Activity

Activity

MIC
Antifungal
40 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 8 Activity

Activity

MIC
Antifungal
30 µM

Target

P. acnes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 9 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020
Evidence 10 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 11 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 12 Activity

Activity

MIC
Antiparasitic
30 µM

Target

P. acnes

Source & Reference

DRAMP

Other

Active against E. coli (MIC 20 uM), S. aureus (MIC 5 uM) and C. albicans (MIC 40 uM), P. acnes (MIC 30 uM) ( Wu et al., 2020 ).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
65-70 µM
Hemolytic Cytotoxic
50% Hemolysis | 65-70 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 14 Activity

Activity

50% Cell death
Toxicity
18 µM
Cytotoxic
50% Cell death | 18 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa. | Peptides | 2007
Evidence 15 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.