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Peptide record

TPDB07639

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07639
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neurotoxin Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 i2APP APD_complete PD_Hemolysis NTxPred2 ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INLLKIAKGIIKSL
Physicochemical Analysis
C72H134N18O17
RDCEQHMFPTWYV
I
1523.97
10.84
3
0
8
+3
0.44
1.057
202.14
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
4
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C72H134N18O17
1523.97
10.84
+3
0.44
1.057
Evidence Records 6 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
100 %
[Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Pept Res. 2004 Sep 64(3):95-103.##Rapid Commun Mass Spectrom. 2000 14(19):1828-1834.##Toxicon. 2000 Nov 38(11):1505-1015.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Antimicrobial and mast cell degranulating peptide. Shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S.aureus ATCC 6538 (MIC=5 ug/ml), S.saprophyticus CS (MIC=5 ug/ml), S.epidermidis CS (MIC=5 ug/ml), B.subtilis CCT 2471 (MIC=40 ug/ml), and the Gram-negative bacteria E.coli CCT 1371 (MIC=20 ug/ml), E.coli ATCC 25922 (MIC=50 ug/ml), and P.aeruginosa ATCC 15442 (MIC=20 ug/ml). Also permeates anionic liposomes. Has little hemolytic activity. Blocks the lobster neuromuscular transmission. Induces the depolarization of the muscle membrane (PubMed:10775751, PubMed:15317499). Its mast cell degranulation activity may be related to the activation of G-protein coupled receptors in mast cells as well as interaction with other proteins located in cell endosomal membranes in the mast cells (By similarity). {ECO:0000250|UniProtKB:P01514, ECO:0000250|UniProtKB:P84914, ECO:0000269|PubMed:10775751, ECO:0000269|PubMed:15317499}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anterhynchium flavomarginatum micado (Solitary wasp)
Neurotoxin Postsynaptic neurotoxin G-protein coupled receptor impairing toxin
Antimicrobial and mast cell degranulating peptide. Shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S.aureus ATCC 6538 (MIC=5 ug/ml), S.saprophyticus CS (MIC=5 ug/ml), S.epidermidis CS (MIC=5 ug/ml), B.subtilis CCT 2471 (MIC=40 ug/ml), and the Gram-negative bacteria E.coli CCT 1371 (MIC=20 ug/ml), E.coli ATCC 25922 (MIC=50 ug/ml), and P.aeruginosa ATCC 15442 (MIC=20 ug/ml).
Eumenine mastoparan-AF (EMP-AF) (Af-113)
insect
MCD family, Mastoparan subfamily
Evidence at protein level
Amidation Antibiotic Antimicrobial Direct protein sequencing G-protein coupled receptor impairing toxin Immunity Innate immunity Mast cell degranulation Membrane Neurotoxin Postsynaptic neurotoxin Secreted Target cell membrane Target membrane Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10775751, ECO:0000305|PubMed:11006592}.
Evidence 3 Activity

Activity

87% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
87% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity and Toxicity of Analogs of Wasp Venom EMP Peptides. Potential Influence of Oxidized Methionine | Antibiotics (Basel) | 2021
Evidence 4 Activity

Activity

93% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
93% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity and Toxicity of Analogs of Wasp Venom EMP Peptides. Potential Influence of Oxidized Methionine | Antibiotics (Basel) | 2021
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 2004 Sep 64(3):95-103.##Rapid Commun Mass Spectrom. 2000 14(19):1828-1834.##Toxicon. 2000 Nov 38(11):1505-1015.
Evidence 6 Hemolysis

Activity

100 %
% Hemolysis
[Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete PD_Hemolysis
J Pept Res. 2004 Sep 64(3):95-103.##Rapid Commun Mass Spectrom. 2000 14(19):1828-1834.##Toxicon. 2000 Nov 38(11):1505-1015.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.
Additional Detail Fields 7 fields
Amidation Antibiotic Antimicrobial Direct protein sequencing G-protein coupled receptor impairing toxin Immunity Innate immunity Mast cell degranulation Membrane Neurotoxin Postsynaptic neurotoxin Secreted Target cell membrane Target membrane Toxin
Neurotoxin Postsynaptic neurotoxin G-protein coupled receptor impairing toxin
Evidence at protein level
MCD family, Mastoparan subfamily
Eumenine mastoparan-AF (EMP-AF) (Af-113)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10775751, ECO:0000305|PubMed:11006592}.
insect