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Peptide record

TPDB07625

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07625

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF dbAMP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Sequence

GIIKKIIKKIIKKI

FASTA

>TPDB07625|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=14
GIIKKIIKKIIKKI

Formula C80H154N20O15

Absent Amino Acids ARNDCEQHLMFPSTWYV

Common Amino Acids I

Mass 1636.23

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +6

Boman Index 3.78

Hydrophobicity 0.550

Aliphatic Index 195.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 7 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C80H154N20O15

Mass

1636.23

11.21

Net Charge

Boman Index

3.78

Hydrophobicity

0.550

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-8 µM

Target

Target Organism B. subtilis ATCC 23857

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

23 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP

Other

Evidence Text

CC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-8 µM

Target

Target Organism B. subtilis ATCC 23857

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source dbAMP

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

23 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP

Other

Evidence Text

CC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiparasitic	dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2-8 µM

Target

Target Organism B. subtilis ATCC 23857

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

23 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

23857 (MIC 2-8 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

CC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), A. baumannii ATCC 19606 (MIC 4 uM).

Evidence 19 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 250 µM

Hemolysis Raw

Human erythrocytes: HC50>250 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Biomaterials. 2014 Feb 35(5):1552-61.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 20 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2000 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 2000 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides. | ACS Appl Mater Interfaces | 2019

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 137 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 137 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

de Novo-designed antimicrobial peptides with broad-spectrum antimicrobial potency and rapid wound disinfection | Colloid Surf A Physicochem Eng Asp | 2023

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 117 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 117 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

de Novo-designed antimicrobial peptides with broad-spectrum antimicrobial potency and rapid wound disinfection | Colloid Surf A Physicochem Eng Asp | 2023

Evidence 23 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >250 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | >250 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

de Novo-designed antimicrobial peptides with broad-spectrum antimicrobial potency and rapid wound disinfection | Colloid Surf A Physicochem Eng Asp | 2023

Evidence 24 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >=250 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >=250 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 25 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Designed antimicrobial and antitumor peptides with high selectivity. | Biomacromolecules | 2011

Evidence 26 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 900 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 900 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides. | ACS Appl Mater Interfaces | 2019

Evidence 27 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >800 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >800 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility? | J Colloid Interface Sci | 2022

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 50±1 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 50±1 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility? | J Colloid Interface Sci | 2022

Evidence 29 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 138.32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 138.32 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

High Therapeutic Index α-Helical AMPs and Their Therapeutic Potential on Bacterial Lung and Skin Wound Infections. | ACS Infect Dis | 2024

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 19.18 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 19.18 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

High Therapeutic Index α-Helical AMPs and Their Therapeutic Potential on Bacterial Lung and Skin Wound Infections. | ACS Infect Dis | 2024

Evidence 31 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 250 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: HC50>250 µM | Cytotoxicity: Human keratinocytes HaCat: <5% Killing=40 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biomaterials. 2014 Feb 35(5):1552-61.

Evidence 32 Hemolysis

Activity

Activity Measurement 250 µM

Activity Endpoint HC50

Hemolysis Raw

Human erythrocytes: HC50>250 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source HemoPI PD_Hemolysis

Reference

Biomaterials. 2014 Feb 35(5):1552-61.

Source DRAMP4

Database Source PD_Hemolysis