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Peptide record

TPDB07615

Antibacterial Antiviral Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07615

Activity

Antibacterial Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

IKWKKLLRAAKRIL

FASTA

>TPDB07615|Antibacterial;Antiviral;Toxicity|length=14
IKWKKLLRAAKRIL

Formula C83H149N25O15

Absent Amino Acids NDCEQGHMFPSTYV

Common Amino Acids K

Mass 1737.25

PI 12.44

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +6

Boman Index 1.09

Hydrophobicity -0.107

Aliphatic Index 153.57

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 316.59

Polar Residues 0

number

Amino Acid Distribution

A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C83H149N25O15

Mass

1737.25

12.44

Net Charge

Boman Index

1.09

Hydrophobicity

-0.107

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µM

Target

Target Organism Staphylococcus aureus USA300 MRSA

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.2 µM

Target

Target Organism Staphylococcus aureus USA300 MRSA

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

active against S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

S. aureus USA300 MRSA (MIC 6.2 uM), E. coli (MIC 3.1 uM), B. subtilis (MIC 12.5 uM), and P. aeruginosa (MIC 6.25 uM).

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 75 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300. | Int J Antimicrob Agents | 2012

Evidence 10 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 1.3 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 1.3 | µM | target cell: CEM-SS cells

Target

Target Cell CEM-SS cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010