Back to search

Peptide record

TPDB07608

LFcin17-30 Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07608
LFcin17-30
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP pep-lab Peptipedia CancerPPD 2.0 Antifungipept CAFPdb CPPsite3.0 HemoPI PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, pep-lab, and other sources, with an available 3D structural model.
Sequence
FKCRRWQWRMKKLG
Physicochemical Analysis
C88H139N29O16S2
ANDEHIPSTYV
RK
1923.38
12.14
6
0
5
+6
0.13
-1.421
27.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
571.91
2
Residue Composition
number
0
A
3
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
1
L
3
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C88H139N29O16S2
1923.38
12.14
+6
0.13
-1.421
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

Pseudomonas aeruginosa Pak

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli O157:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. naeslundii

Source & Reference

dbAMP

Other

ve against Gram- E. coli O157:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.gingivalis HG 66

Source & Reference

dbAMP

Other

57:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

B. subtilis ATCC 9372

Source & Reference

dbAMP

Other

inosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (M
Evidence 5 Activity

Activity

MIC
Antibacterial
5.5 µM

Target

S. sanguis SK4

Source & Reference

dbAMP

Other

ii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
5.5 µM

Target

S. mutans

Source & Reference

dbAMP

Other

HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

lis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1.5 µM

Target

Pseudomonas aeruginosa Pak

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli O157:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372
Evidence 9 Activity

Activity

MIC
Antifungal
10 µM

Target

A. naeslundii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ve against Gram- E. coli O157:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4
Evidence 10 Activity

Activity

MIC
Antifungal
>100 µM

Target

P.gingivalis HG 66

Source & Reference

dbAMP CAFPdb Antifungipept

Other

57:H7 or K12 (MIC 1.8-1.9 uM), P. aeruginosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5
Evidence 11 Activity

Activity

MIC
Antifungal
10 µM

Target

B. subtilis ATCC 9372

Source & Reference

dbAMP CAFPdb Antifungipept

Other

inosa Pak (MIC 1.5 uM), A. naeslundii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (M
Evidence 12 Activity

Activity

MIC
Antifungal
5.5 µM

Target

S. sanguis SK4

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ii (MIC 10 uM), P.gingivalis HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
5.5 µM

Target

S. mutans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

HG 66 (MIC>100 uM), Gram+ B. subtilis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
1.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lis ATCC 9372 (MIC 10 uM), S. sanguis SK4 (MIC 5.5 uM), S. mutans (MIC 5.5 uM), and yeast C. albicans ATCC 10231 (MIC 1.5 uM).
Evidence 15 Activity

Activity

Cell-penetrating Peptides

Target

Enteroaggregative Escherichia Coli (Eaec)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cytoplasm
After 30 min of incubation LFcin17-30, LFampin265-284 and LFchimera can be found in the EAEC cytoplasm, and only a low proportion of the peptides were visualized on the membrane.
Membrane distruption
In vitro
CCCCSGGGSSCC
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fungicidal effect of three new synthetic cationic peptides against Candida albicans. | Oral Dis | 2004
Evidence 17 Activity

Activity

<15% Hemolysis
Toxicity
<50 µM
Hemolytic Cytotoxic
<15% Hemolysis | <50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin. | Peptides | 2004
Evidence 18 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
CCCCSGGGSSCC