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Peptide record

TPDB07605

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

14 amino acids

3D PDB MODEL

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TPDB ID TPDB07605

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KKKKPLFGLFFGLF

FASTA

>TPDB07605|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=14
KKKKPLFGLFFGLF

Formula C87H132N18O15

Absent Amino Acids ARNDCEQHIMSTWYV

Common Amino Acids KF

Mass 1670.12

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index -1.77

Hydrophobicity 0.329

Aliphatic Index 83.57

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 4 M: 0 F: 4 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C87H132N18O15

Mass

1670.12

11.00

Net Charge

Boman Index

-1.77

Hydrophobicity

0.329

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 24-48 µM

Target

Target Organism S. thyphimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

(MIC 3–6 uM) and V. splendidus (MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 24-48 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 24-48 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 24-48 µM

Target

Target Organism S. thyphimurium

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

(MIC 3–6 uM) and V. splendidus (MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 24-48 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 24-48 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 24-48 µM

Target

Target Organism S. thyphimurium

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

(MIC 3–6 uM) and V. splendidus (MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 24-48 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 24-48 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 24-48 µM

Target

Target Organism S. thyphimurium

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

(MIC 3–6 uM) and V. splendidus (MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 24-48 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

MIC 3–6 uM), and human pathogenic gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 24-48 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

gram-negative bacteria: S. thyphimurium (MIC 24-48 uM), P. aeruginosa (MIC 24-48 uM) and K. pneumoniae (MIC 24-48 uM).

Evidence 13 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 40 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 40 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

KKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity. | Peptides | 2009

Evidence 14 Activity

Activity

Activity Endpoint 7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 160 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

7% Hemolysis | 160 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

KKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity. | Peptides | 2009

Evidence 15 Activity

Activity

Activity Endpoint 24% Cell death

Detail Source Activity Toxicity

Activity Measurement 160 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

24% Cell death | 160 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Target Cell Chinese hamster ovary cells CHO-K1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

KKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity. | Peptides | 2009

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: [Ref.19573572] No significant hemolytic activity is observed at 10 and 40 µg/ml. Slight hemolysis (6.65%) is shown at 160 µg/ml. | Cytotoxicity: [Ref.19573572] The cell viability of CHO-K1 cells is 127%, 123%,78% and 10% at peptide concentrations of 10 µg/ml, 40 µg/ml, 160 µg/ml and 640 µg/ml

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2009 Sep 30(9):1608-12