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Peptide record

TPDB07604

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07604
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INWKALLDAAKKVL
Physicochemical Analysis
C75H127N19O18
RCEQGHMFPSTY
ALK
1582.95
10.32
3
1
9
+2
0.34
0.421
153.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
347.45
1
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C75H127N19O18
1582.95
10.32
+2
0.34
0.421
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 3 Activity

Activity

MIC
Antibacterial
3.9 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 4 Activity

Activity

MIC
Antibacterial
3.9 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

t E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 5 Activity

Activity

MIC
Antifungal
7.8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/m
Evidence 6 Activity

Activity

MIC
Antifungal
62.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 7 Activity

Activity

MIC
Antifungal
3.9 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 8 Activity

Activity

MIC
Antifungal
3.9 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 9 Activity

Activity

MIC
Antiparasitic
7.8 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/m
Evidence 10 Activity

Activity

MIC
Antiparasitic
62.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 11 Activity

Activity

MIC
Antiparasitic
3.9 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 12 Activity

Activity

MIC
Antiparasitic
3.9 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

t E. coli (MIC 7.8 ug/ml), P. aeruginosa (MIC 62.5 ug/ml), S. aureus (MIC 3.9 ug/ml), and B. subtilis (MIC 3.9 ug/ml) ( de Souza et al.,2011 ).
Evidence 13 Activity

Activity

Hemolysis
[Ref.20108158]ED50 =3.4 × 10−5 M against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Nat Toxins. 1993 1(5):271-276.##Toxicon. 2010 Apr 1 55(4):711-718.##Amino Acids. 2011 Jan 40(1):77-90.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems. | Biochim Biophys Acta | 2014
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems. | Biochim Biophys Acta | 2014
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
34 µM
Hemolytic Cytotoxic
50% Hemolysis | 34 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities | Amino Acids | 2011
Evidence 17 Activity

Activity

50% Degranulation
Toxicity
80 µM
Cytotoxic
50% Degranulation | 80 | µM | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems. | Biochim Biophys Acta | 2014
Evidence 18 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.20108158]ED50 =3.4 × 10−5 M against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Nat Toxins. 1993 1(5):271-276.##Toxicon. 2010 Apr 1 55(4):711-718.##Amino Acids. 2011 Jan 40(1):77-90.
Evidence 19 Hemolysis

Activity

[Ref.20108158]ED50 =3.4 × 10−5 M against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

PD_Hemolysis
Nat Toxins. 1993 1(5):271-276.##Toxicon. 2010 Apr 1 55(4):711-718.##Amino Acids. 2011 Jan 40(1):77-90.
DRAMP4
PD_Hemolysis