TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07569

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

FIGALLGPLLNLLK

FASTA

>TPDB07569|Antibacterial;Antifungal;Hemolysis;Toxicity|length=14
FIGALLGPLLNLLK

Formula C73H124N16O16

Absent Amino Acids RDCEQHMSTWYV

Common Amino Acids L

Mass 1481.88

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -3.09

Hydrophobicity 1.579

Aliphatic Index 202.14

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

1

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

6

L

1

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 6 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

14

Formula

C73H124N16O16

Mass

1481.88

PI

10.10

Net Charge

+1

Boman Index

-3.09

Hydrophobicity

1.579

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 10.5 %

Hemolysis Raw

[Ref.25312021]10.5% Hemolysis against Rat erythrocytes at 20 µM.

Target

RBC Target Rat erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

FEBS J. 2015 Jan 282(1):102-13.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 11% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

11% Hemolysis | 20 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis. | FEBS J | 2015

Evidence 3 Activity

Activity

Activity Endpoint 70% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

70% Hemolysis | 50 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin. | J Biochem | 2016

Evidence 4 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10.5 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.25312021]10.5% Hemolysis against Rat erythrocytes at 20 µM.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

FEBS J. 2015 Jan 282(1):102-13.

Evidence 5 Hemolysis

Activity

Activity Measurement 10.5 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.25312021]10.5% Hemolysis against Rat erythrocytes at 20 µM.

Detail Source Activity Hemolysis

Target

RBC Target Rat erythrocytes

Source & Reference

source APD_complete PD_Hemolysis

Reference

FEBS J. 2015 Jan 282(1):102-13.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.