TPDB07558

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. bauma

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aur

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

e against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovi

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism L. ivanovii Li 4pVS2

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

5923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans ATCC 90028

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesv

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism C. parapsilosis ATCC 22019

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesvirus 1 (HSV-1) (EC50 6.22 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. bauma

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aur

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

e against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovi

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism L. ivanovii Li 4pVS2

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C.

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

5923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans ATCC 90028

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

IC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesv

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism C. parapsilosis ATCC 22019

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesvirus 1 (HSV-1) (EC50 6.22 uM).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. bauma

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

Active against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aur

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

e against Gram- E. coli ATCC 25922 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

12.5 uM), P. aeruginosa ATCC 27853 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovi

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

25 uM), K. pneumoniae ATCC 13883 (MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes ATCC 19615

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

MIC 6.25 uM), A. baumannii ATCC 19606 (MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism L. ivanovii Li 4pVS2

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

(MIC 3 uM), Gram+ S. aureus ATCC 25923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C.

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

5923 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM).

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans ATCC 90028

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

IC 6.25 uM), L. ivanovii Li 4pVS2 (MIC 50 uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesv

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism C. parapsilosis ATCC 22019

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

uM), E.faecalis ATCC 29212 (MIC >100 uM), fungi C. albicans ATCC 90028 (MIC 12.5 uM), and C. parapsilosis ATCC 22019 (MIC 25 uM). Virus: Inhibited entry of Human alphaherpesvirus 1 (HSV-1) (EC50 6.22 uM).

Evidence 31 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan. | Biochim Biophys Acta | 2016

Evidence 32 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement >200 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | >200 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan. | Biochim Biophys Acta | 2016

Evidence 33 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.27423268]LC50>200 µM against rat red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochim Biophys Acta. 2016 Nov 1858(11):2699-2708.