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Peptide record

TPDB07545

Antibacterial Antiparasitic Antiviral Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07545
Antibacterial Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antiparasitic, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
ALWKTMLKKLGTMA
Physicochemical Analysis
C73H126N18O17S2
RNDCEQHIFPSYV
LK
1592.03
10.84
3
0
8
+3
-1.07
0.314
97.86
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
345.47
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
3
K
2
M
0
F
0
P
0
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 3 M: 2 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C73H126N18O17S2
1592.03
10.84
+3
-1.07
0.314
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
85 µM
Cytotoxic
50% Cytotoxicity | 85 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50>100 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50=85 µM 293TT(embryonic human culture cells):CC50>100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.