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Peptide record

TPDB07529

Antibacterial Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07529

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

IRIRCRRRFCRIRI

FASTA

>TPDB07529|Antibacterial;Toxicity|length=14
IRIRCRRRFCRIRI

Formula C81H149N35O15S2

Absent Amino Acids ANDEQGHLKMPSTWYV

Common Amino Acids R

Mass 1917.42

PI 12.53

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +7

Boman Index 2.82

Hydrophobicity -0.407

Aliphatic Index 111.43

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.52

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 7 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C81H149N35O15S2

Mass

1917.42

12.53

Net Charge

Boman Index

2.82

Hydrophobicity

-0.407

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 1 uM), S. Pullorum C79-13 (MIC 1 uM), S. enterica serovar Typhimurium C77-31 (MIC 4 uM), B. yoc

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism S. Pullorum C79-13

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 1 uM), S. Pullorum C79-13 (MIC 1 uM), S. enterica serovar Typhimurium C77-31 (MIC 4 uM), B. yocyaneum ATCC 27853 (MIC 4 uM), G

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. enterica serovar Typhimurium C77-31

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 1 uM), S. Pullorum C79-13 (MIC 1 uM), S. enterica serovar Typhimurium C77-31 (MIC 4 uM), B. yocyaneum ATCC 27853 (MIC 4 uM), Gram+ S. aeurus ATCC 29213 (MIC 4 uM), S. epidermidi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. yocyaneum ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

1 uM), S. Pullorum C79-13 (MIC 1 uM), S. enterica serovar Typhimurium C77-31 (MIC 4 uM), B. yocyaneum ATCC 27853 (MIC 4 uM), Gram+ S. aeurus ATCC 29213 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. faecalis

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. aeurus ATCC 29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

enterica serovar Typhimurium C77-31 (MIC 4 uM), B. yocyaneum ATCC 27853 (MIC 4 uM), Gram+ S. aeurus ATCC 29213 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. faecalis ATCC 29212 (MIC 4 uM), and B. subtilis

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

31 (MIC 4 uM), B. yocyaneum ATCC 27853 (MIC 4 uM), Gram+ S. aeurus ATCC 29213 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. faecalis ATCC 29212 (MIC 4 uM), and B. subtilis CMCC 63501 (MIC 2 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. faecalis ATCC 29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 4 uM), Gram+ S. aeurus ATCC 29213 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. faecalis ATCC 29212 (MIC 4 uM), and B. subtilis CMCC 63501 (MIC 2 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. subtilis CMCC 63501

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. faecalis ATCC 29212 (MIC 4 uM), and B. subtilis CMCC 63501 (MIC 2 uM).

Evidence 9 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial potency and selectivity of simplified symmetric-end peptides. | Biomaterials | 2014

Evidence 10 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. | J Med Chem | 2022

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 37.1 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 37.1 | µM | target cell: Human kidney proximal tubule HK-2 cells

Target

Target Cell Human kidney proximal tubule HK-2 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. | J Med Chem | 2022

Evidence 12 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.24621994] MHC10=128 µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

PLoS One. 2014 Mar 12 9(3):e91007. doi: 10.1371/journal.pone.0091007.