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Peptide record

TPDB07526

Antibacterial Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07526

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.

Sequence

IKWKAILDAVKKVI

FASTA

>TPDB07526|Antibacterial;Toxicity|length=14
IKWKAILDAVKKVI

Formula C79H137N19O17

Absent Amino Acids RNCEQGHMFPSTY

Common Amino Acids K

Mass 1625.07

PI 10.55

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +3

Boman Index 1.65

Hydrophobicity 0.664

Aliphatic Index 167.14

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 338.45

Polar Residues 0

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2

Length

Formula

C79H137N19O17

Mass

1625.07

10.55

Net Charge

Boman Index

1.65

Hydrophobicity

0.664

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32-64 µg/mL

Target

Target Organism Staphylococcus aureus CCRC12652 or CCRC15211

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ S. aureus CCRC12652 or CCRC15211 (MIC 32-64 ug/ml), S. xylosus (MIC 2 ug/ml), S. alactolyticus (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism S. xylosus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ S. aureus CCRC12652 or CCRC15211 (MIC 32-64 ug/ml), S. xylosus (MIC 2 ug/ml), S. alactolyticus (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml), E. coli BL21 or JM109 Am

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism S. alactolyticus

Source & Reference

Database Source NA

Other

Evidence Text

ainst Gram+ S. aureus CCRC12652 or CCRC15211 (MIC 32-64 ug/ml), S. xylosus (MIC 2 ug/ml), S. alactolyticus (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml), E. coli BL21 or JM109 Amp (MIC 8 ug/ml), K. pneumoniae CC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism C. koseri

Source & Reference

Database Source NA

Other

Evidence Text

15211 (MIC 32-64 ug/ml), S. xylosus (MIC 2 ug/ml), S. alactolyticus (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml), E. coli BL21 or JM109 Amp (MIC 8 ug/ml), K. pneumoniae CCRC10694 (MIC 32 ug/ml), S. Chol

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli BL21 or JM109 Amp

Source & Reference

Database Source NA

Other

Evidence Text

S. xylosus (MIC 2 ug/ml), S. alactolyticus (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml), E. coli BL21 or JM109 Amp (MIC 8 ug/ml), K. pneumoniae CCRC10694 (MIC 32 ug/ml), S. Choleraesuis (MIC 32 ug/ml), S. typhimurium C

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Klebsiella pneumoniae CCRC10694

Source & Reference

Database Source NA

Other

Evidence Text

s (MIC 12 ug/ml), Gram- C. koseri (MIC 4 ug/ml), E. coli BL21 or JM109 Amp (MIC 8 ug/ml), K. pneumoniae CCRC10694 (MIC 32 ug/ml), S. Choleraesuis (MIC 32 ug/ml), S. typhimurium CCRC12947 (MIC 32 ug/ml), V. parahamelyti

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism S. Choleraesuis

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), E. coli BL21 or JM109 Amp (MIC 8 ug/ml), K. pneumoniae CCRC10694 (MIC 32 ug/ml), S. Choleraesuis (MIC 32 ug/ml), S. typhimurium CCRC12947 (MIC 32 ug/ml), V. parahamelytics CCRC10806 (MIC 16 ug/ml), and

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism S. typhimurium CCRC12947

Source & Reference

Database Source NA

Other

Evidence Text

mp (MIC 8 ug/ml), K. pneumoniae CCRC10694 (MIC 32 ug/ml), S. Choleraesuis (MIC 32 ug/ml), S. typhimurium CCRC12947 (MIC 32 ug/ml), V. parahamelytics CCRC10806 (MIC 16 ug/ml), and P.aeruginosa (MIC 192 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism V. parahamelytics CCRC10806

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 32 ug/ml), S. Choleraesuis (MIC 32 ug/ml), S. typhimurium CCRC12947 (MIC 32 ug/ml), V. parahamelytics CCRC10806 (MIC 16 ug/ml), and P.aeruginosa (MIC 192 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 192 µg/mL

Target

Target Organism P.aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

S. typhimurium CCRC12947 (MIC 32 ug/ml), V. parahamelytics CCRC10806 (MIC 16 ug/ml), and P.aeruginosa (MIC 192 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint 4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

4% Hemolysis | 32 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 12 Activity

Activity

Activity Endpoint 8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

8% Hemolysis | 64 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 13 Activity

Activity

Activity Endpoint 17% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

17% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 14 Activity

Activity

Activity Endpoint 27% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

27% Hemolysis | 256 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 15 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 16 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 17 Activity

Activity

Activity Endpoint 14% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

14% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011

Evidence 18 Activity

Activity

Activity Endpoint 37% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

37% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011