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Peptide record

TPDB07499

Antibacterial Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07499
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKWRKLLKKLKKLL
Physicochemical Analysis
C89H163N25O15
ANDCEQGHIMFPSTYV
K
1823.43
11.93
8
0
6
+8
3.09
-0.979
139.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
301.63
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
7
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C89H163N25O15
1823.43
11.93
+8
3.09
-0.979
Evidence Records 5 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 2 Activity

Activity

17% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
17% Hemolysis | 64 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>64 µg/mL
Cytotoxic
50% Cell death | >64 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27591703] 0% hemolysis at 64 µg/ml against human red blood cells 10% hemolysis at 64 µg/ml against sheep red blood cells | Cytotoxicity: [Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 99.2%, 95.4%, 93.8%, 91.9%, 77.3% and 55.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µg/mL within 24h.

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Mar 89(3):327-338. doi: 10.1111/cbdd.12864.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis