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Peptide record

TPDB07494

Antibacterial standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07494
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
YYHFWHRGVTKRSL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C88H124N26O19
ANDCEQIMP
RHY
1850.12
10.59
5
0
6
+3
2.55
-0.993
48.57
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
8480
4.58
4
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
2
H
0
I
1
L
1
K
0
M
1
F
0
P
1
S
1
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 1 K: 1 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 2 V: 1
Chemical Descriptors
14 reviewed residue count
C88H124N26O19 sequence-only estimate (linear, free termini)
1850.12 sequence-only estimate (linear, free termini)
10.59 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
2.55 sequence-only estimate (linear, free termini)
-0.993 sequence-only estimate (linear, free termini)
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 30 uM), P. aeruginosa (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus
Evidence 2 Activity

Activity

MIC
Antibacterial
60 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 30 uM), P. aeruginosa (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (
Evidence 3 Activity

Activity

MIC
Antibacterial
80 µM

Target

S. enterica

Source & Reference

NA

Other

Active against E. coli (MIC 30 uM), P. aeruginosa (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (M
Evidence 4 Activity

Activity

MIC
Antibacterial
70 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E. coli (MIC 30 uM), P. aeruginosa (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (MIC >100 uM) and E. faecali
Evidence 5 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

IC 30 uM), P. aeruginosa (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (MIC >100 uM) and E. faecalis (MIC 70 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
80 µM

Target

B. subtilis

Source & Reference

NA

Other

a (MIC 60 uM) S. enterica (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (MIC >100 uM) and E. faecalis (MIC 70 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.pyogenes

Source & Reference

NA

Other

a (MIC 80 uM) K. pneumoniae (MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (MIC >100 uM) and E. faecalis (MIC 70 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
70 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

MIC 70 uM) S. aureus (MIC 60 uM) B. subtilis (MIC 80 uM) S.pyogenes (MIC >100 uM) and E. faecalis (MIC 70 uM).