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Peptide record

TPDB07490

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07490
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WRKLWRGGLKRWLK
Physicochemical Analysis
C91H143N29O15
ANDCEQHIMFPSTYV
RLKW
1883.32
12.71
6
0
6
+6
-1.81
-1.236
83.57
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
876.11
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
14
C91H143N29O15
1883.32
12.71
+6
-1.81
-1.236
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Central ?-turn increases the cell selectivity of imperfectly amphipathic ?-helical peptides. | Acta Biomater | 2018
Evidence 2 Activity

Activity

83.5% Cell death
Toxicity
64 µM
Cytotoxic
83.5% Cell death | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Central ?-turn increases the cell selectivity of imperfectly amphipathic ?-helical peptides. | Acta Biomater | 2018
Evidence 3 Activity

Activity

25.9% Cell death
Toxicity
64 µM
Cytotoxic
25.9% Cell death | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Central ?-turn increases the cell selectivity of imperfectly amphipathic ?-helical peptides. | Acta Biomater | 2018