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Peptide record

TPDB07477

Antibacterial standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07477
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RWLKKRRWKYYVPP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C97H146N28O17
ANDCEQGHIMFST
RK
1976.40
11.52
6
0
6
+6
3.43
-1.771
48.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
7.07
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
0
M
0
F
2
P
0
S
0
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 2 V: 1
Chemical Descriptors
14 reviewed residue count
C97H146N28O17 sequence-only estimate (linear, free termini)
1976.40 sequence-only estimate (linear, free termini)
11.52 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.43 sequence-only estimate (linear, free termini)
-1.771 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

NA

Other

Active against P. aeruginosa ATCC 27853 or PAO1 (MIC 1-2 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), and S. aureus ATCC 29213 (MIC 64 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against P. aeruginosa ATCC 27853 or PAO1 (MIC 1-2 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), and S. aureus ATCC 29213 (MIC 64 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

t P. aeruginosa ATCC 27853 or PAO1 (MIC 1-2 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), and S. aureus ATCC 29213 (MIC 64 ug/ml).