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Peptide record

TPDB07464

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07464
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LILGKLWKGVKSIF
Physicochemical Analysis
C80H132N18O16
ARNDCEQHMPTY
LK
1602.04
10.84
3
0
8
+3
-2.09
0.943
160.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
343.31
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
3
L
3
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C80H132N18O16
1602.04
10.84
+3
-2.09
0.943
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50-100 µg/mL

Target

Escherichia coli AB94012 or ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli AB94012 or ATCC25922 (MIC 50-100 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC259
Evidence 2 Activity

Activity

MIC
Antibacterial
25-100 µg/mL

Target

Pseudomonas aeruginosa AB93066 or ATCC9027

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli AB94012 or ATCC25922 (MIC 50-100 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374 (MIC 6.25-25 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25-25 µg/mL

Target

Staphylococcus aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374

Source & Reference

dbAMP DRAMP

Other

ATCC25922 (MIC 50-100 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374 (MIC 6.25-25 ug/ml).
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
K1K8: an Hp1404-derived antibacterial peptide. | Appl Microbiol Biotechnol | 2016
Evidence 5 Activity

Activity

12% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
K1K8: an Hp1404-derived antibacterial peptide. | Appl Microbiol Biotechnol | 2016
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic
Hemolytic_activity: [Ref.26952110] 2% hemolysis at 200µg/mL, 10% hemolysis at 400µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Appl Microbiol Biotechnol. 2016 Jun 100(11):5069-77.