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Peptide record

TPDB07446

Antibacterial Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07446
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INWKKLLDAAKQIL
Physicochemical Analysis
C78H132N20O19
RCEGHMFPSTYV
LK
1654.03
10.32
3
1
8
+2
0.71
0.064
153.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
332.52
2
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C78H132N20O19
1654.03
10.32
+2
0.71
0.064
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 5.8 ug/ml), P. aeruginosa (MIC 46.8 ug/ml), S. aureus (MIC 7.8 ug/ml), and B. subtilis (MIC 4.9 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
46.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5.8 ug/ml), P. aeruginosa (MIC 46.8 ug/ml), S. aureus (MIC 7.8 ug/ml), and B. subtilis (MIC 4.9 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
7.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5.8 ug/ml), P. aeruginosa (MIC 46.8 ug/ml), S. aureus (MIC 7.8 ug/ml), and B. subtilis (MIC 4.9 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
4.9 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

t E. coli (MIC 5.8 ug/ml), P. aeruginosa (MIC 46.8 ug/ml), S. aureus (MIC 7.8 ug/ml), and B. subtilis (MIC 4.9 ug/ml).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
26 µM
Hemolytic Cytotoxic
50% Hemolysis | 26 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
The effect of acidic residues and amphipathicity on the lytic activities of mastoparan peptides studied by fluorescence and CD spectroscopy. | Amino Acids | 2011
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis