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Peptide record

TPDB07444

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07444
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILGKLWEGVKSIF
Physicochemical Analysis
C75H119N17O18
ARNDCQHMPTY
G
1546.87
9.88
2
1
7
+1
-0.49
0.671
132.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
355.56
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C75H119N17O18
1546.87
9.88
+1
-0.49
0.671
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-16 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
AB93113, B. subtilis AB91021, S. aureus MRSA P1381, S. aureus MRSA P1374, E. faecium, and S. agalactiae (MIC 4-16 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
4-16 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
AB93113, B. subtilis AB91021, S. aureus MRSA P1381, S. aureus MRSA P1374, E. faecium, and S. agalactiae (MIC 4-16 uM).
Evidence 3 Activity

Activity

% Hemolysis
Hemolysis
2 11 55 92 100 %
[Ref.29379033]Hemolysis 2% at 12.5 µM against mouse red blood cell, hemolysis 11% at 25.0 µM against mouse red blood cell, hemolysis 55% at 50.0 µM against mouse red blood cell, hemolysis 92% at 100.0 µM against mouse red blood cell, hemolysis 100% at 200.0 µM against mouse red blood cell

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Sci Rep. 2018 Jan 29 8(1):1763.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. | PLoS One | 2014
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
226.6 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 226.6 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. | PLoS One | 2014
Evidence 6 Activity

Activity

50% Cell death
Toxicity
>100 µg/mL
Cytotoxic
50% Cell death | >100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. | PLoS One | 2014
Evidence 7 Activity

Activity

2% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
2% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. | Sci Rep | 2018
Evidence 8 Activity

Activity

11% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
11% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. | Sci Rep | 2018
Evidence 9 Activity

Activity

55% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
55% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. | Sci Rep | 2018
Evidence 10 Activity

Activity

92% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
92% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. | Sci Rep | 2018
Evidence 11 Activity

Activity

100% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
100% Hemolysis | 200 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. | Sci Rep | 2018
Evidence 12 Activity

Activity

10% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of the scorpion venom-derived antimicrobial peptide Hp1404 as a new antimicrobial agent against carbapenem-resistant Acinetobacter baumannii. | Microb Pathog | 2021
Evidence 13 Activity

Activity

49.2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
49.2% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Comparative Antimicrobial Activity of Hp404 Peptide and Its Analogs against Acinetobacter baumannii. | Int J Mol Sci | 2021
Evidence 14 Activity

Activity

27.7% Killing
Toxicity
50 µM
Cytotoxic
27.7% Killing | 50 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Comparative Antimicrobial Activity of Hp404 Peptide and Its Analogs against Acinetobacter baumannii. | Int J Mol Sci | 2021
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29379033]Hemolysis 2% at 12.5 µM against mouse red blood cell, hemolysis 11% at 25.0 µM against mouse red blood cell, hemolysis 55% at 50.0 µM against mouse red blood cell, hemolysis 92% at 100.0 µM against mouse red blood cell, hemolysis 100% at 200.0 µM against mouse red blood cell | Cytotoxicity: [Ref.29379033] The cell survial against HaCaT cells is 85%, 26%, 5% and 6% at peptide concentrations of 25, 50, 100 and 200 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2018 Jan 29 8(1):1763.
Evidence 16 Hemolysis

Activity

2 11 55 92 100 %
% Hemolysis
[Ref.29379033]Hemolysis 2% at 12.5 µM against mouse red blood cell, hemolysis 11% at 25.0 µM against mouse red blood cell, hemolysis 55% at 50.0 µM against mouse red blood cell, hemolysis 92% at 100.0 µM against mouse red blood cell, hemolysis 100% at 200.0 µM against mouse red blood cell
Hemolysis

Source & Reference

APD_complete PD_Hemolysis
Sci Rep. 2018 Jan 29 8(1):1763.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.