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Peptide record

TPDB07441

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07441

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPPSPWKETFRTS

FASTA

>TPDB07441|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=14
FLPPSPWKETFRTS

Formula C81H117N19O21

Absent Amino Acids ANDCQGHIMYV

Common Amino Acids P

Mass 1692.93

PI 10.09

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 4

Net Charge +1

Boman Index 1.04

Hydrophobicity -0.800

Aliphatic Index 27.86

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 324.88

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 2 P: 3 S: 2 T: 2 W: 1 Y: 0 V: 0

Length

Formula

C81H117N19O21

Mass

1692.93

10.09

Net Charge

Boman Index

1.04

Hydrophobicity

-0.800

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 42.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 85 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nst E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 42.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml)

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 85 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 42.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml)

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 85 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

nst E. coli (MIC 42.5 ug/ml), S. aureus (MIC 21.3 ug/ml), B. subtilis (MIC 85 ug/ml), and C. albicans (MIC 21.3 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 14 Activity

Activity

Activity Endpoint (17.6±6.1)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(17.6±6.1)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007