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Peptide record

TPDB07438

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07438
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SILGKLWKGVKSIF
Physicochemical Analysis
C77H126N18O17
ARNDCEQHMPTY
K
1575.96
10.84
3
0
7
+3
-1.40
0.614
132.14
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
348.99
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
2
L
3
K
0
M
1
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C77H126N18O17
1575.96
10.84
+3
-1.40
0.614
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

Escherichia coli AB94012 or ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli AB94012 or ATCC25922 (MIC 25-50 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-50 ug/ml), Gram+ S. aureus AB94004 or ATCC2592
Evidence 2 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

Pseudomonas aeruginosa AB93066 or ATCC9027

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli AB94012 or ATCC25922 (MIC 25-50 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-50 ug/ml), Gram+ S. aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374 (MIC 6.25-12.5 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25-12.5 µg/mL

Target

Staphylococcus aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374

Source & Reference

dbAMP DRAMP

Other

r ATCC25922 (MIC 25-50 ug/ml), P. aeruginosa AB93066 or ATCC9027 (MIC 25-50 ug/ml), Gram+ S. aureus AB94004 or ATCC25923 or MRSA P1381 or MRSA P1374 (MIC 6.25-12.5 ug/ml).
Evidence 4 Activity

Activity

15% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
K1K8: an Hp1404-derived antibacterial peptide. | Appl Microbiol Biotechnol | 2016
Evidence 5 Activity

Activity

45% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
K1K8: an Hp1404-derived antibacterial peptide. | Appl Microbiol Biotechnol | 2016
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic
Hemolytic_activity: [Ref.26952110] 15% hemolysis at 200µg/mL, 45% hemolysis at 400µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Appl Microbiol Biotechnol. 2016 Jun 100(11):5069-77.