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Peptide record

TPDB07435

Antibacterial Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB07435
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
KALWKTLLKKVLKA
Physicochemical Analysis
C80H142N20O16
RNDCEQGHIMFPSY
K
1640.13
11.12
5
0
8
+5
0.73
0.136
146.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
335.34
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
5
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C80H142N20O16
1640.13
11.12
+5
0.73
0.136
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
55±10 µM
Hemolytic Cytotoxic
50% Hemolysis | 55±10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Physicochemical properties that enhance discriminative antibacterial activity of short dermaseptin derivatives. | Antimicrob Agents Chemother | 2006
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
70±11 µM
Hemolytic Cytotoxic
50% Hemolysis | 70±11 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Physicochemical properties that enhance discriminative antibacterial activity of short dermaseptin derivatives. | Antimicrob Agents Chemother | 2006
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
10±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 10±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Physicochemical properties that enhance discriminative antibacterial activity of short dermaseptin derivatives. | Antimicrob Agents Chemother | 2006
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis