Back to search

Peptide record

TPDB07419

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07419
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLLRKFFRKLKKSV
Physicochemical Analysis
C86H151N27O16
ANDCEQGHIMPTWY
K
1819.32
12.72
7
0
6
+7
2.65
-0.621
104.29
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
4
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 4 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C86H151N27O16
1819.32
12.72
+7
2.65
-0.621
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids. | Eur J Pharm Sci | 2017
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28522372]2% hemolysis at 800 µg/ml against mice red blood cells | Cytotoxicity: The percentages of possible occurring conformations involved helix, beta, turn and random are also quantified in various solutions

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2017 Jul 15 105:169-177.
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28522372]1% hemolysis at 800 µg/ml against mice red blood cells | Cytotoxicity: [Ref.28522372] In mice spleen cells, the peptide produced cell viability of 97% at 800 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2017 Jul 15 105:169-182.