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Peptide record

TPDB07404

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07404
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FKRINQRIKDFLR
Physicochemical Analysis
C79H132N26O18
ACEGHMPSTWYV
R
1734.08
12.13
5
1
5
+4
3.20
-1.031
90.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C79H132N26O18
1734.08
12.13
+4
3.20
-1.031
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>1280 µM
Hemolytic Cytotoxic
10% Hemolysis | >1280 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. | ChemMedChem | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23894079] MHC10>1280 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.