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Peptide record

TPDB07401

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07401
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLRALWNVAKSVF
Physicochemical Analysis
C76H115N19O16
DCEQGHIMPTY
ALFV
1550.87
11.49
2
0
9
+2
-3.08
0.892
120.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
354.64
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C76H115N19O16
1550.87
11.49
+2
-3.08
0.892
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
0% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
25 %
Hemolytic
Hemolytic_activity: [Ref.31212183] 25% hemolysis at 6.3 µmol/L, 65% hemolysis at 25 µmol/L, 75% hemolysis at 50 µmol/L, 100% hemolysis at 100 µmol/L for human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2019 Jun 8 90:103038. doi: 10.1016/j.bioorg.2019.103038.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis