TPDB

3D PDB MODEL

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TPDB ID TPDB07400

Peptide_Name

FK13

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia DBAASP

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and DBAASP, with an available 3D structural model.

Sequence

FPLTWLKWWKWKK

FASTA

>TPDB07400|Antibacterial;Toxicity|length=13
FPLTWLKWWKWKK

Formula C98H135N21O15

Absent Amino Acids ARNDCEQGHIMSYV

Common Amino Acids KW

Mass 1847.28

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index -5.10

Hydrophobicity -0.854

Aliphatic Index 60.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 1190.94

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

4

K

0

M

1

F

1

P

0

S

1

T

4

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 1 P: 1 S: 0 T: 1 W: 4 Y: 0 V: 0

Length

13

Formula

C98H135N21O15

Mass

1847.28

PI

11.00

Net Charge

+4

Boman Index

-5.10

Hydrophobicity

-0.854

Evidence 1 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 500 | µg/mL | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations. | Nat Biomed Eng | 2021

Evidence 2 Activity

Activity

Activity Endpoint 10% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 80 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

10% Cytotoxicity | 80 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning | Research Square | 2023

Evidence 3 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 64 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning | Research Square | 2023

Evidence 4 Activity

Target

Target Organism Cutibacterium acnes

Source & Reference

Database Source DBAASP