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Peptide record

TPDB07396

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07396
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb dbAMP 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGALWNVKKSVF
Physicochemical Analysis
C75H113N17O16
RDCEQHIMPTY
LKFV
1508.83
10.60
2
0
8
+2
-2.72
0.769
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
364.52
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C75H113N17O16
1508.83
10.60
+2
-2.72
0.769
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
<5% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. | Eur J Pharm Sci | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31181304] 0% hemolysis at 100 µmol/L against human red blood cells | Cytotoxicity: [Ref.31181304] The cell viability of MCF-7 cells induced by [Lys9]-VmCT1-NH2 is 120%, 120%, 105%, 110%, 110%, 108%, 120% and 120% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2019 Jun 7 136:104952. doi: 10.1016/j.ejps.2019.06.006.